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Danazol is a synthetic hormone, prescribed as one type of treatment for endometriosis. It acts by suppressing the brain's production of follicle stimulating hormone and hence suppresses ovarian function. This is similar to an artificial menopause and results in the shrinking of not only the endometrium in the uterus (as a result of which the periods stop while taking danazol); but also hopefully the misplaced patches of endometrium outside the uterus found in patients with endometriosis, causing them to disappear.
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Side Effects: These are as follows; hot flushes, weight gain, acne, hirsutism (hairiness). These side effects are quite troublesome, and some women have to discontinue the drug because of these. Usually, while taking danazol, the periods will stop completely - a condition called pseudomenopause.
Dose: The standard dose used to be 800 mg daily (4 tablets of 200 mg each). However, the side-effects at this dose are considerable, and many doctors have reported good results with doses as low as 200 mg daily. The usual course of treatment is 6-9 months and the extent of the improvement in endometriosis is then reviewed. Danazol is expensive medication, and is usually not advised for women with endometriosis who are trying to get pregnant.Steroids: Dexamethasone is often used as an adjunct to ovulation induction treatment, especially in patients with hirsutism who have high levels of androgens. It helps by suppressing the production of androgens by the adrenal glands. The dose is usually a 0.5 mg tablet, taken daily at bedtime. Side-effects at such a low dose are unusual, but dexamethasone is a potent drug, and should be used under careful medical supervision.
© Dr. Aniruddha Malpani and Dr. Anjali Malpani www.drmalpani.com
Credits: How to Have a Baby: Overcoming Infertility
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