Bromocriptine Mesylate

Classification

Ergot alkaloids

Brand Names

Parlodelę, Ergosetę

Form

Tablets or capsules

Indications

Corrective for ovarian dysfunction as a result of elevated prolactin levels (hyperprolactinemia) with:

  • no indication of pituitary tumor
  • no current pregnancy
  • no severe ischemic heart disease or peripheral vascular disorders
  • normal liver function

Also used to treat prolactin-secreting pituitary adenomas and Parkinson's disease.

Suggested Evaluations

Pre-RX

  • existence of current pregnancy
  • current breastfeeding
  • hypertension or hypotension, heart disease, or peripheral vascular disease
  • mental illness
  • seizures
  • pituitary tumor
  • prolactin levels
  • unusual/allergic reactions to bromocriptine or other ergot alkaloids, sulfites, or any other foods or medicines

During RX

  • Blood pressure
  • Liver functions
  • Renal functions
  • Dosage related side effects

Usual Dosage

One (1) 1.25 to 2.5 mg. tablet daily. May be increased to 2.5 mg. tablets 2 to 3 times daily.

Instructions

Take with food to avoid GI tract side effects, and at regular intervals. Missed doses should be taken as soon as possible, unless it is more than 4 hours since missed dose was due (in that case, wait until next dose). Do not double up doses. Dizziness and fainting may occur, particularly during the first dose in some patients. Take first dose in evening to cope with possible drowsiness effect. Avoid driving or using heavy machinery until you know how the drug effects you. Regular menses usually recurs in 6 to 8 weeks.

Common side effects

  • Drowsiness
  • Fatigue
  • Nasal congestion or discharge
  • Dry mouth
  • Mental confusion

Side effects to report to your doctor

  • Any symptoms of shock
  • Vomiting
  • Blurred vision
  • Irregular heartbeat
  • Breathing difficulty
  • Continual dizziness or fainting spells
  • Hypotension (low blood pressure)

Precautions

  • Category C: Safe use in pregnant women not yet established. Therapy should be discontinued promptly if conception occurs.
  • Use with caution in the presence of impaired renal or hepatic (liver) function.
  • Use with caution in presence of psychiatric disorder history.
  • Caution with history of heart arrhythmia.
  • Will stop breastmilk production.
  • Long-term effects unknown, so treatment not to exceed 6 months.

Drug interactions or incompatibility

  • Decreased effect with: Amitriptyline, butyrophenones, imipramine, tricyclic antidepressants, methyldopa, phenothiazines, reserpine, oral contraceptives, estrogen, progestins, erythromycin
  • Increased toxicity with: other ergot alkaloids
  • Decreased tolerance to alcohol
Visitor Comments (1)
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Bhawani - 1 year ago
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Thanks a lot. #1