Medroxyprogesterone Acetate

Classification

Progesterone derivative

Brand Names

Provera , Depo-Provera

Form

2.5, 5, or 10 mg Oral tablets (Provera) or intramuscular injection (Depo-Provera)

Indications

Secondary amenorrhea (Provera), Contraception (Depo-Provera), with:

  • No current pregnancy
  • No breastfeeding
  • Liver dysfunction or disease
  • No thrombotic disorders
  • Known or suspected malignancy of breast or genital organs
  • Undiagnosed unusual vaginal bleeding
  • Incomplete miscarriage

Used for

Inducing a menstrual period in cases of amenorrhea (lack of menstrual bleeding). Also used for long-term contraception and for palliative treatment of advanced endometrial or renal carcinoma.

How does it work?

Possesses hormonal activities of follicle stimulating hormone (FSH).

Suggested Evaluations

Pre-RX

  • thyroid disease
  • ovarian enlargement or cyst formation
  • uterine fibroid tumors
  • undiagnosed unusual vaginal bleeding
  • estrogen levels
  • primary pituitary or ovarian failure or enlargement
  • evidence of prostate cancer in men
  • testicular failure
  • renal and hepatic functions

During RX

  • mid-cycle urine LH test (OPK)
  • estrogen levels
  • progesterone levels
  • mid-cycle ultrasound to detect follicle development

Usual Dosage

Provera
5 to 10 mgs daily for 5 to 10 days.
Depo-Provera
Injection by medical practitioner at 3-month intervals.

Instructions

For amenorrhea
May be started at any time during cycle. Withdrawal bleeding usually begins within 3 to 7 days after discontinuing tablets.
For contraception
Must be started during first 5 days of menstrual period to assure no pregnancy exists.

Common side effects

  • Injection site pain
  • Lower abdomen tenderness
  • Fluid retention
  • Headache
  • Emotional irritability
  • Breast discomfort
  • Fatigue
  • Multiple births

Side effects to report to your doctor

  • Severe pain or swelling in lower abdomen or extremities
  • Shortness of breath
  • Vomiting or diarrhea

Precautions

  • Pregnancy Category X: May cause birth defects if used during pregnancy.
  • Exercise caution if patient is breastfeeding.
  • May result in ovarian hyperstimulation.
  • May result in multiple births.

Drug interactions or incompatibility

Herbal preparations using blue or black cohosh.

Visitor Comments (0) - Be the first to comment
Adding your comments contributes to the adoption community. Please keep all comments on topic and civil. Visitors are invited to comment and vote for or flag comments based on appropriateness and helpfulness. All comments must adhere to our commenting rules and are subject to moderation.