CrinoneŽ (mfg. Wyeth-Ayerst), Prometrium (mfg. Solvay)
Oil injections, suppositories, and oral troches, compounded at individual pharmacies.
Demonstrated ovulatory dysfunction with:
- No current pregnancy
- No evidence of primary ovarian failure
- No uncontrolled thyroid or adrenal dysfunction
- No ovarian cysts (except in case of PCOS)
- Used in conjunction with hCG
Maintaining pregnancy or potential pregnancy in second half of treatment cycle.
How does it work?
Possesses hormonal activities of follicle stimulating hormone (FSH).
- thyroid disease
- ovarian enlargement or cyst formation
- uterine fibroid tumors
- undiagnosed unusual vaginal bleeding
- estrogen levels
- primary pituitary or ovarian failure or enlargement
- evidence of prostate cancer in men
- testicular failure
- renal and hepatic functions
- mid-cycle urine LH test (OPK)
- estrogen levels
- progesterone levels
- mid-cycle ultrasound to detect follicle development
Dosage must be carefully determined for each patient, and may be changed during treatment cycle.
During a fertility treatment cycle in women, 75 units to 600 units injected once daily for 6 to ten days, beginning on CD (cycle day) 2 or 3.
Administered beginning day following hCG injection (usually mid-cycle) and continuing until negative pregnancy test or later in first trimester.
Common side effects
- Injection site pain
- Lower abdomen tenderness
- Fluid retention
- Emotional irritability
- Breast discomfort
- Multiple births
Side effects to report to your doctor
- Severe pain or swelling in lower abdomen or extremities
- Shortness of breath
- Vomiting or diarrhea
- Pregnancy Category X: May cause birth defects if used during pregnancy.
- Exercise caution if patient is breastfeeding.
- May result in ovarian hyperstimulation.
- May result in multiple births.
Drug interactions or incompatibility
Herbal preparations using blue or black cohosh.
© Tracy Morris